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Stomatologija 2022; 24 (4): 104-11 240 KB

Second generation platelet concentrates in periodontal surgery: A narrative review and clinical perspectives

Emilija Migauskaitė^*, Jūratė Žekonienė^*, Arūnas Rimkevičius^*, Giedrius Krukonis^*

Summary

Objective. The aim of this article is to analyze the latest scientific literature and focus on the development of second-generation platelet concentrates: platelet-rich fibrin (PRF) and concentrated growth factor (CGF), their fabrication procedure and capability in periodontal surgery.

Material and methods. Scientific articles published in English were selected from PubMed and Cochrane Library databases according to selected keywords. Duplicate and off-topic articles were excluded from further analysis.

Conclusion. PRF and CGF can be considered beneficial biomaterials because they are reported to have favorable biological effects, are low in cost and easier to prepare compared to first generation platelet concentrates and do not cause side effects. Although PRF and CGF demonstrate promising results in the regeneration of intrabony defects, further research is needed. Same as with furcation defect therapy - more evidence of use of PRF or CGF is necessary. In gingival recession treatment PRF or CGF is not yet suggested as first option for treatment as connective tissue graft is still preferable.

Key words: PRF, CGF, furcation defect, growth factors, intrabony defect, gingival recession.

Received: 22 03 2022

Accepted for publishing: 27 12 2022

^*Institute of Odontology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

Address correspondence to Emilija Migauskaitė, Institute of Odontology, Faculty of Medicine, Vilnius University, Žalgirio g. 117, 08217 Vilnius, Lithuania.

E-mail address: emilija.migauskaite@zalgirioklinika.lt



	Baltic Dental and Maxillofacial Journal

2022, Vol. 24, No. 4 CONTENTS REVIEW Surgical treatment methods of medication-related osteonecrosis of the jaw. A systematic review Jonas Zigmantavičius, Gerda Kilinskaitė, Ričardas Kubilius 91-99 Association between apical periodontitis and root canal treatment in patients with type II diabetes. A systematic review Karolina Budreikaitė, Mariam Varoneckaitė, Danielė Oleinikaitė, Juozas Žilinskas 100-103 Second generation platelet concentrates in periodontal surgery: A narrative review and clinical perspectives Emilija Migauskaitė, Jūratė Žekonienė, Arūnas Rimkevičius, Giedrius Krukonis 104-111 Prevalence of peri-implantitis and peri-mucositis in pristine and augmented bone in periodontally compromised patients. A literature review Nomeda Basevičienė, Austė Bendoraitytė-Antipovienė, Ugnė Mikelionytė 112-124 © 2023 Stomatologija		Stomatologija 2022; 24 (4): 104-11 240 KB Second generation platelet concentrates in periodontal surgery: A narrative review and clinical perspectives Emilija Migauskaitė^, Jūratė Žekonienė^, Arūnas Rimkevičius^, Giedrius Krukonis^ Summary Objective. The aim of this article is to analyze the latest scientific literature and focus on the development of second-generation platelet concentrates: platelet-rich fibrin (PRF) and concentrated growth factor (CGF), their fabrication procedure and capability in periodontal surgery. Material and methods. Scientific articles published in English were selected from PubMed and Cochrane Library databases according to selected keywords. Duplicate and off-topic articles were excluded from further analysis. Conclusion. PRF and CGF can be considered beneficial biomaterials because they are reported to have favorable biological effects, are low in cost and easier to prepare compared to first generation platelet concentrates and do not cause side effects. Although PRF and CGF demonstrate promising results in the regeneration of intrabony defects, further research is needed. Same as with furcation defect therapy - more evidence of use of PRF or CGF is necessary. In gingival recession treatment PRF or CGF is not yet suggested as first option for treatment as connective tissue graft is still preferable. Key words: PRF, CGF, furcation defect, growth factors, intrabony defect, gingival recession. Received: 22 03 2022 Accepted for publishing: 27 12 2022 ^*Institute of Odontology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania Address correspondence to Emilija Migauskaitė, Institute of Odontology, Faculty of Medicine, Vilnius University, Žalgirio g. 117, 08217 Vilnius, Lithuania. E-mail address: emilija.migauskaite@zalgirioklinika.lt