|Baltic Dental and Maxillofacial Journal|
June, 2004, Vol. 6, No. 2
© 2004 Stomatologija
Stomatologija 2004; 6 (2): 55-8 253 KB
Alkaline Phosphatase Activity Changes of Blood Neutrophil Leukocytes Among Patients Suffering from Diabetes Mellitus Type I and Periodontal Diseases
Jurgina Sakalauskiene, Egle Ivanauskiene, Gediminas Zekonis, Juozas Zilinskas
The aim of this work was to investigate secretion function of peripheral venous blood neutrophil leukocytes (NL) in the effect of stimulators of bacterial origin: E. coli, S. aureus, opsonized zymozan for patients with insulin dependent diabetes mellitus (1 TDM) and periodontal disease, patients with periodontal disease without systematic pathology and healthy donors. Activity of NL degranulation was analyzed for 32 patients with 1 TDM, 37 patients with periodontal disease and somatically healthy. 35 healthy donors, with healthy periodontal tissues formed the control group.
Neutrophil leukocytes, that are affected by stimulators of bacterial origin in non-cellular environment among patients with 1 TDM and periodontal disease, without generic diseases secrete considerably higher amount (p= 0,001) of alkaline phosphates than neutrophil leukocytes of patients without periodontal disease in analogical medium.
Neutrophil leukocytes affected by microbial origin stimuli in non cellular environment, can release lysosomic ferments which might cause destruction of periodontal tissue.
Key words: neutrophil leukocytes, alkaline phosphatase, insulin-dependent diabetes mellitus (1 TDM).
Received: 02 02 2004
Accepted for publishing: 20 05 2004
Jurgina Sakalauskiene - D.D.S., PhD, assoc.prof., Clinic of Prosthetic Denstistry, Kaunas Medical University, Lithuania.
Egle Ivanauskiene D.D.S., ass.prof., Clinic of Prosthetic Denstistry, Kaunas Medical University, Lithuania.
Gediminas Zekonis - D.D.S., PhD, assoc.prof., Clinic of Prosthetic Denstistry, Kaunas Medical University, Lithuania.
Juozas Zilinskas - D.D.S., Odontologic Clinic, private practice, Kaunas, Lithuania.
Address correspondence to Dr.Jurgina Sakalauskiene, Clinic of Prosthetic Dentistry, Sukileliu 51, Kaunas, Lithuania.