www.sbdmj.com - Stomatologija - Baltic Dental and Maxillofacial Journal

Stomatologija 2021; 23 (3): 86-9 176 KB

Is there an association with Wilson’s disease and multiple tongue dysplasia lesions and in situ carcinoma? A case-report based literature review

Dimitris Tatsis¹, Aggeliki Baliaka², Konstantinos Antoniades³

Summary

Wilson’s Disease (WD) is a rare autosomal recessive hereditary disease with copper accumulation in the body, particularly the liver, brain and cornea. WD is widely treated with chelation agents who enable the copper excretion. Since high concentrations of copper are toxic, WD is associated with hepatocellular carcinoma and cholangiocarcinoma, with low incidence of other types of cancer. We present a case of a 33 year old man who was treated in the Oral and Maxillofacial Surgery Department of the Aristotle University of Thessaloniki with multiple dysplasia lesions and an in situ carcinoma of the tongue, which is to our knowledge the first case report of oral lesions to a patient with WD. Literature is reviewed on copper levels on patients with head and neck cancer, and on chelation agents and their effect on cancer cells.

Key words: oral cancer, Wilson’s disease, precancerous lesions, copper.

Received: 04 03 2020

Accepted for publishing: 24 09 2021

¹Department of Oral and Maxillofacial Surgery, General Hospital G. Papanikolaou, Thessaloniki, Greece

²Department of Pathology, General Hospital G. Papanikolaou, Thessaloniki, Greece

³Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece

Address correspondence to Dimitris Tatsis, Department of Oral and Maxillofacial Surgery, General Hospital Georgios Papanikolaou Exochi, 57010, Greece.

E-mail address: dtatsis@outlook.com



	Baltic Dental and Maxillofacial Journal

September, 2021, Vol. 23, No. 3 CONTENTS REVIEW The effect of botox for the correction of the gummy smile: A systematic review Augustė Razmaitė, Giedrė Trakinienė 63-68 SCIENTIFIC ARTICLES Immediate implant supported prosthodontic treatment of the edentulous jaw with additional implant stabilization Roman А. Rozov 69-74 REVIEW Could saliva play a role in controlling the Covid-19 pandemic? Anna Papadopoulou, Despina Tounta, Christina Tesseromatis 75-79 SCIENTIFIC ARTICLES Knowledge, attitude and practice of dental house surgeons and undergraduate students towards radiation safety and protection: A questionnaire based survey Kirthana Muthu A/P Shanmugam, Ananya Madival, Supriya Bhat, Siti Dzulaikha Amalina Binti Jelani 80-85 CASE REPORTS Is there an association with Wilson’s disease and multiple tongue dysplasia lesions and in situ carcinoma? A case-report based literature review Dimitris Tatsis, Aggeliki Baliaka, Konstantinos Antoniades 86-89 Canalicular adenoma of minor salivary gland. Report of a case and a brief review of the literature Karakostas Panagiotis, Matiakis Apostolos, Anagnostou Eleftherios, Poulopoulos Athanasios 90-92 © 2021 Stomatologija		Stomatologija 2021; 23 (3): 86-9 176 KB Is there an association with Wilson’s disease and multiple tongue dysplasia lesions and in situ carcinoma? A case-report based literature review Dimitris Tatsis¹, Aggeliki Baliaka², Konstantinos Antoniades³ Summary Wilson’s Disease (WD) is a rare autosomal recessive hereditary disease with copper accumulation in the body, particularly the liver, brain and cornea. WD is widely treated with chelation agents who enable the copper excretion. Since high concentrations of copper are toxic, WD is associated with hepatocellular carcinoma and cholangiocarcinoma, with low incidence of other types of cancer. We present a case of a 33 year old man who was treated in the Oral and Maxillofacial Surgery Department of the Aristotle University of Thessaloniki with multiple dysplasia lesions and an in situ carcinoma of the tongue, which is to our knowledge the first case report of oral lesions to a patient with WD. Literature is reviewed on copper levels on patients with head and neck cancer, and on chelation agents and their effect on cancer cells. Key words: oral cancer, Wilson’s disease, precancerous lesions, copper. Received: 04 03 2020 Accepted for publishing: 24 09 2021 ¹Department of Oral and Maxillofacial Surgery, General Hospital G. Papanikolaou, Thessaloniki, Greece ²Department of Pathology, General Hospital G. Papanikolaou, Thessaloniki, Greece ³Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece Address correspondence to Dimitris Tatsis, Department of Oral and Maxillofacial Surgery, General Hospital Georgios Papanikolaou Exochi, 57010, Greece. E-mail address: dtatsis@outlook.com