|Baltic Dental and Maxillofacial Journal|
June, 2011, Vol. 13, No. 2
Relationship between radiographic changes in the temporomandibular joint and bone mineral density: A population based study
© 2011 Stomatologija
Stomatologija 2011; 13 (2): 49-54 262 KB
Prognostic factors and epidemiological characteristics of cutaneous and mucosal head and neck melanoma
Anna Berzina, Kristine Azarjana, Ingrida Cema, Dace Pjanova, Alexander Rivosh
The objective. To describe the prognostic factors and epidemiological characteristics of cutaneous and mucosal head and neck melanoma and to identify the variables associated with mortality from this disease.
Material and methods. Patients treated for head and neck melanoma in the Oncology Centre of Latvia, Riga during a 10-year period were identified. Records from 124 cases were analyzed in a descriptive, retrospective study. For each patient, information regarding age, sex, tumor anatomic site, as well as ulceration, histological tumor subtypes, Breslow thickness and Clark invasion level was viewed. Disease specific survival rates were calculated. The frequencies of all study variables and their 95% confidence intervals were determined. Kaplan-Meier survival curves were produced to illustrate the survival diferences for each variable.
Results. The patients’ mean age was 67.36 years. The study included 81 females (65.32%) and 43 males (34.67%). The prevalent anatomical site for cutaneous head and neck melanoma was the cheek 49% (n=55) and the intraocular site for mucosal melanoma (61.5%). A high percentage of thick cutaneous melanoma was detected. In 53 cases (47.3%) out of 112 cutaneous melanoma the tumor ulceration was found. Nodular melanoma subtype was predominating (38%). The incidence of cutaneous melanoma has increased unequally whereas mucosal melanoma of the head and neck is an uncommon cancer and the incidence rates in Latvia during a ten year period are decreasing.
Conclusion. Female sex, advanced age, facial skin, tumor thickness, nodular subtype and ulceration carried a relevant risk of poor prognosis.
Key words: head and neck melanoma, survival, mortality.
Received: 21 10 2010
Accepted for publishing: 24 06 2011
1The Clinic of Laserplastics, Riga, Latvia
2Riga Stradins University, Doctoral Studies
3Riga Stradins University; The Oncology Center of Latvia
4Latvian Biomedical Research and Study Centre
5University of Latvia, Faculty of Computing
Anna Berzina1 Dr. Med.
Kristine Azarjana2 PhD student
Ingrida Cema3 Dr. Habil. Med., prof.
Dace Pjanova4 PhD, researcher
Alexander Rivosh5 MSc. comp., researcher
Address correspondence to Dr. Anna Berzina, Vairoga Street 38-1, Riga LV-1039, Latvia.