International Scientific-Practical Conference “The Art And Science Of Orthodontics” February 6-7, 2026, Kaunas, Lithuania

REVIEWS

Clinical efficacy of aligners with mandibular advancement in treatment of Class II malocclusions compared to conventional functional appliances: A systematic review
Deimantė Kuzminskaite, Jurga Liatukienė, Juozas Žilinskas
2-9

SCIENTIFIC ARTICLES

Effect of menopausal estrogen deficiency on dentin formation: A comparative analysis of mineralization front and predentin thickness in pre and postmenopausal women
Andamuthu Yamunadevi, D. B. Nandini, Mandana Donogh, Praveen S. Basandi,
Manickam Selvamani, G. S. Madhushankari
10-16

REVIEWS

Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review
Benas Ilekis, Salma Varoneckaitė, Juozas Žilinskas
17-23

CASE REPORTS

The formation of epithelial orbital cysts secondary to orbital implants and reconstruction with computer-assisted manufactured patient-specific implant: A two-part case series
Fiona L. Guan, Paul Hankinson, Sachin M. Salvi, Nicholas J. Lee
24-28

Diagnosis of secretory carcinoma of the upper lip: A rare case report and literature review
Caroline Alfaia-Silva, Túlio Silva Rosa, Paulo Victor Mendes Penafort, Larissa Tinô de Carvalho Silva, Amanda Almeida Leite, Renata d'Andrada Tenório Almeida Silva, Catarina Rodrigues Rosa de Oliveira, Sonia Maria Soares Ferreira, Ricardo Luiz Cavalcanti Albuquerque-Júnior
29-32

Stomatologija 2026; 28 (1): 17-23 135 KB

Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review

Benas Ilekis¹, Salma Varoneckaitė², Juozas Žilinskas³

Summary

Background. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) emerges as a serious side effect of bisphosphonate treatment worldwide, significantly impairing patients‘ oral health and overall quality of life. Ongoing research shows emerging treatment modalities such as a combination of pentoxifylline and tocopherol, teriparatide, and platelet concentrates that enhances the prospects of BRONJ treatment. However, the need for more accurate and predictable treatment options still remains. The aim of this review is to summarize and ascertain the current prevention and treatment strategies of BRONJ.

Materials and methods. A narrative literature review was conducted using the PubMed, Wiley Online Library, ScienceDirect, and Springer databases using the Medical Subject Headings (MeSH) terms including “Osteonecrosis of the Jaw,” “Disphosphonates,” “Teriparatide,” “Platelet-Rich Plasma,” and “Pentoxifylline“. Inclusion criteria comprised clinical studies involving human subjects that evaluated prevention or treatment strategies for bisphosphonate-related osteonecrosis of the jaw. Randomized controlled trials, prospective and retrospective cohort studies, and clinical comparative studies published in English between 2015 and 2025. The literature search was conducted in January 2025.

Results. Emerging prevention and treatment strategies, including teriparatide and the combination of pentoxifylline and tocopherol, show potential in improving clinical outcomes and reducing disease progression.

Conclusions. Although emerging treatment methods show promising results, BRONJ continues to pose significant clinical challenges.

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¹Institute of Dentistry, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

²Faculty of Odontology, Medical Academy (MA), Lithuanian University of Health Sciences, Kaunas, Lithuania

³Department of Prosthodontics, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspondence to Benas Ilekis , Institute of Dentistry, Faculty of Medicine, Vilnius University, Žalgirio St. 117, Vilnius, Vilnius City Municipality 08217, Lithuania.

E-mail address: benas.ilekis@mf.stud.vu.lt