International Scientific-Practical Conference “The Art And Science Of Orthodontics” February 6-7, 2026, Kaunas, Lithuania

REVIEWS

Clinical efficacy of aligners with mandibular advancement in treatment of Class II malocclusions compared to conventional functional appliances: A systematic review
Deimantė Kuzminskaite, Jurga Liatukienė, Juozas Žilinskas
2-9

SCIENTIFIC ARTICLES

Effect of menopausal estrogen deficiency on dentin formation: A comparative analysis of mineralization front and predentin thickness in pre and postmenopausal women
Andamuthu Yamunadevi, D. B. Nandini, Mandana Donogh, Praveen S. Basandi,
Manickam Selvamani, G. S. Madhushankari
10-16

REVIEWS

Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review
Benas Ilekis, Salma Varoneckaitė, Juozas Žilinskas
17-23

CASE REPORTS

The formation of epithelial orbital cysts secondary to orbital implants and reconstruction with computer-assisted manufactured patient-specific implant: A two-part case series
Fiona L. Guan, Paul Hankinson, Sachin M. Salvi, Nicholas J. Lee
24-28

Diagnosis of secretory carcinoma of the upper lip: A rare case report and literature review
Caroline Alfaia-Silva, Túlio Silva Rosa, Paulo Victor Mendes Penafort, Larissa Tinô de Carvalho Silva, Amanda Almeida Leite, Renata d'Andrada Tenório Almeida Silva, Catarina Rodrigues Rosa de Oliveira, Sonia Maria Soares Ferreira, Ricardo Luiz Cavalcanti Albuquerque-Júnior
29-32

Stomatologija 2026; 28 (1): 2-9 291 KB

Clinical efficacy of aligners with mandibular advancement in treatment of Class II malocclusions compared to conventional functional appliances: A systematic review

Deimantė Kuzminskaite¹, Jurga Liatukienė¹, Juozas Žilinskas²

Summary

Background and objectives. Clear aligners were initially limited to the treatment of mild malocclusions. Recent advancements have expanded their use to skeletal Class II correction through mandibular advancement features designed to mimic conventional functional appliances. However, evidence regarding their clinical effectiveness, particularly compared with traditional functional appliances, remains limited. The aim of this systematic review is to evaluate the clinical effectiveness of clear aligners with mandibular advancement in the management of Class II malocclusion, in comparison with conventional functional orthopedic appliances.

Material and methods. The protocol of the systematic review is in line with the PRISMA requirements, papers published in English language between 2020 and 2025 were searched in PubMed, ScienceDirect, The Cochrane Library and Google Scholar databases using the PICO framework. The ROBINS-I tool was used to assess the risk of bias.

Results. A total of 726 articles were identified. After eliminating duplicates and applying eligibility criteria, nine studies involving 412 patients were included, primarily using cephalometric analyses to evaluate skeletal and dental changes before and after treatment. Despite variability in the parameters assessed and methodologies used, both aligners with mandibular advancement and conventional functional appliances showed similar skeletal and dental correction. Consistent reductions in overbite and overjet, increases in SNB as well as decreases in ANB and Wits appraisal.

Conclusion. Aligners with mandibular advancement appear to be an effective option for treating Class II malocclusions in growing patients, demonstrating similar dentoalveolar and skeletal effects to conventional functional appliances. However, methodological limitations and heterogeneity among studies restrict the strength of the evidence.

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¹Private practice, UAB Klaipėdos ortodontijos centras, Klaipėda, Lithuania

²Department of Prosthodontics, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspo ndence to Deimantė Kuzminskaitė, UAB Klaipėdos ortodontijos centras, Taikos pr. 22A, Klaipėda, Lithuania.

E-mail address: deimante.kuzminskaite@gmail.com