REVIEWS

The role of antibiotic prophylaxis for healthy patients in tooth extraction and implantation procedures: A systematic review
Pranas Grinkevičius, David Kasradze, Aleksandr Kasradze, Albinas Gervickas, Juozas Žilinskas
57-67

SCIENTIFIC ARTICLES

Estimation of Human Islet Antigen Insulinoma-Associated-2 Autoantibody and Zinc Transporter 8 Autoantibody levels in saliva and serum in generalized periodontitis patients with and without Type 2 Diabetes mellitus – A cross-sectional study
Irene Ann Thomas, Ashish S Nichani, BS Jagadish Pai
68-76

Comparative analysis of indicators of primary stability of implants of different implantological systems at immediate implantation
Dmytro Kaplun, David Avetikov, Serhii Balyuk, Olena Ivanytska, Кateryna Lokes, Ihor Ivanytskyi
77-82

RETROSPECTIVE STUDY

Oral squamous cell carcinoma: An epidemiological and descriptive study of 29 cases
Marcelo Rodrigues Azenha, Luis Guilherme Brentegani, Giovani Antonio Rodrigues,
Suzie Aparecida de Lacerda
83-86

Stomatologija 2024; 26 (3): 57-67 245 KB

The role of antibiotic prophylaxis for healthy patients in tooth extraction and implantation procedures: A systematic review

Pranas Grinkevičius¹, David Kasradze¹, Aleksandr Kasradze¹, Albinas Gervickas², Juozas Žilinskas³

Summary

Background and objectives. Prophylactic antibiotics are frequently prescribed following outpatient oral surgical procedures to minimize the risk of surgical site infections. However, the overuse of antibiotics contributes to microbial resistance and increases the likelihood of adverse side effects. This highlights the need for a rational approach in assessing the necessity and appropriate dosing of antibiotics after outpatient oral surgeries. The primary aim of this study was to systematically analyze the literature on the use of prophylactic antibiotics in outpatient oral surgery.

Materials and methods. Scientific articles were selected following PRISMA guidelines. The review included randomized controlled trials (RCTs) published in English between 2013 and 2023. Data searches were conducted on PubMed, ClinicalKey, and Cochrane Library databases.

Results. A total of 15 RCTs involving 3,032 participants were included in this review. Of these, six studies reported no statistically significant differences between groups in terms of post-operative outcomes. In contrast, six studies focusing on tooth extraction reported significant differences in pain, swelling, trismus, and bleeding between the groups. Additionally, three studies on dental implant procedures revealed significant differences concerning implant failure rates, flap closure, and pain levels. Despite these findings, the overall evidence did not demonstrate statistically significant benefits of prophylactic antibiotics in reducing post-operative infectious complications. Furthermore, no evidence was found to support the importance of timing in the administration of prophylactic antibiotic therapy.

Conclusions. The findings of this systematic review do not support the routine use of prophylactic antibiotics for healthy patients to prevent post-operative infections in outpatient oral surgical procedures. Further research is needed to establish clear guidelines on the necessity and optimal timing of antibiotic use in such cases.

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¹Lithuanian University of Health Sciences, Kaunas, Lithuania

²Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania

³Department of Prosthodontics, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspo ndence to Pranas Grinkevičius, Lithuanian University of Health Sciences, A.Mickeviciaus 9, LT-44307, Kaunas, Lithuania.

E-mail address: pranasgrinkevicius@gmail.com