|Baltic Dental and Maxillofacial Journal|
March, 2020, Vol. 22, No. 1
Tendencies of FGFR2 rs2981582 polymorphism in patients with oral cancer
Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region
Sodium hypochlorite accidents in dentistry. A systematic review of published case reports
Clear cell odontogenic carcinoma: a rare pathology with an innovative resolution
© 2020 Stomatologija
Stomatologija 2020; 22 (1): 23-7 216 KB
Autologous platelet concentrates in treatment of medication related osteonecrosis of the jaw
Henrikas Rusilas1, Aušra Balčiūnaitė2, Juozas Žilinskas3
Background. Medication related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction occurring as a progressive bone destruction in the maxillofacial region. MRONJ is usually initiated after oral surgery procedures, however periodontal disease and other chronic inflammations are also risk factors. There is no clear treatment protocol for management of MRONJ, for this reason autologous platelet concentrates (APC) have been introduced to enhance the healing process.
Aim. To evaluate the effectiveness of APCs in treatment of MRONJ.
Methods. A systematic literature review was performed according to PRISMA guidelines in MEDLINE (PubMed) and Google Scholar databases. Only no older than 5 years, in vivo studies in English with follow-up until condition totally resolves were included.
Results. A total of 2683 publications were identified out of which only 7 met the inclusion criteria, 6 cohort and 1 randomized clinical trial. Most of the studies preferred platelet rich fibrin (PRF) and only one used platelet rich plasma (PRP) in MRONJ treatment. MRONJ stage, patients mean age, drug therapy, follow-up and success rate were analysed in all the studies. Five studies also named how MRONJ initiated and 4 studies mentioned duration of drug intake before developing MRONJ.
Conclusion. The published data is not sufficient to confirm a specific treatment protocol although the published results are promising. More prospective randomized controlled clinical trials are required in order to evaluate the effectiveness of APCs for treatment of MRONJ.
Key words: osteonecrosis, medication, platelet, concentrates, surgery.
Received: 06 06 2019
Accepted for publishing: 21 03 2020
1Department of Oral and Maxillofacial surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
2Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas Lithuania
3Department of Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, Lithuania
Address correspondence to Henrikas Rusilas, Department of Oral and Maxillofacial surgery, Lithuanian University of Health Sciences, Sukilėlių pr. 69-19, 49325 Kaunas, Lithuania.