Baltic Dental and Maxillofacial Journal
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March, 2020, Vol. 22, No. 1

CONTENTS

SCIENTIFIC ARTICLES

Tendencies of FGFR2 rs2981582 polymorphism in patients with oral cancer
Vykintas Liutkevicius, Toma Tamauskaite, Alvita Vilkeviciute, Rasa Liutkeviciene, Rasa Smalinskaite, Agne Giedraitiene, Alina Smalinskiene, Virgilijus Uloza
3-8

REVIEWS

Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region
Egils Kornevs, Ingus Arnolds Apse, Toms Janis Safronovs, Aija Krastina, Arturs Paparde, Gunars Lauskis, Girts Salms

9-16

Sodium hypochlorite accidents in dentistry. A systematic review of published case reports
Shishir Ram Shetty, Sura Ali Ahmed Fuoad Al-Bayati, Ashwin Narayanan, Mohammed Said Hamed, Hossam Abdelatty Eid Abdemagyd, Praveen Shetty

17-22

Autologous platelet concentrates in treatment of medication related osteonecrosis of the jaw
Henrikas Rusilas, Aušra Balčiūnaitė, Juozas Žilinskas

23-27

CASE REPORT

Clear cell odontogenic carcinoma: a rare pathology with an innovative resolution
Natalia Lucía Gómez, Luis Boccalatte, Alejandro Yanzón, María Gabriela Nassif, Juan José Larrañaga, Marcelo Fernando Figari
28-32


© 2020 Stomatologija

Stomatologija 2020; 22 (1): 3-8 186 KB

Tendencies of FGFR2 rs2981582 polymorphism in patients with oral cancer

Vykintas Liutkevicius1, Toma Tamauskaite2, Alvita Vilkeviciute3, Rasa Liutkeviciene3, Rasa Smalinskaite2, Agne Giedraitiene4, Alina Smalinskiene5, Virgilijus Uloza1

Summary

Objective. Fibroblast growth factor receptor 2 (FGFR2) is a member of the FGFR family of tyrosine kinase receptors, which via cell growth, invasiveness, motility and angiogenesis contributes to the process of tumorogenesis. A huge interest today is focused on FGFR2 gene polymorphism as it may have a significant impact on the development of various benign and malignant tumors.

A case-control study was designed to help determine if FGFR2 gene polymorphism rs2981582 is associated with oral cancer in Lithuanian subjects.

Methods. The study included 35 patients with a diagnosis of oral cancer and 100 healthy subjects as a reference group. DNA samples were extracted from peripheral venous blood. Genotyping of FGFR2 rs2981582 was performed using the real-time polymerase chain reaction method. Statistical analysis was performed using „IBM SPSS Statistics 20.0“.

Results. It was determined that FGFR2 gene rs2981582 polymorphism has no effect on a development of oral cancer. The analysis of FGFR2 gene polymorphisms did not reveal any differences in the distribution of GG, GA, and AA genotypes between the oral cancer group, and the control group (42.9%, 48.6%, and 8.6% vs. 46%, 37% and 17%, respectively).

Conclusion. Results of present study showed no association between FGFR2 gene polymorphisms rs2981582 and oral cancer. However, a further study with a larger sample sizes is advisable.

Key words: fibroblast growth factor receptor 2, gene polymorphism, oral cancer.

Received: 18 02 2019

Accepted for publishing: 21 03 2020


1Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

2Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

3Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania

4Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Kaunas, Lithuania

5Institute of Cardiology, Medicine Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspondence to Rasa Liutkeviciene, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, Eivenių 2, Kaunas, Lithuania.

E-mail address: rliutkeviciene@gmail.com