Baltic Dental and Maxillofacial Journal
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2023, Vol. 25, No. 1


© 2023 Stomatologija

Stomatologija 2023; 25 (1): 11-20 237 KB

Systemic and topical treatment methods of recurrent aphthous stomatitis: A systematic review

Karolis Skučas1, Aušra Balčiūnaitė2, Nomeda Basevičienė2


Aim. To analyze the latest systemic and topical recurrent aphthous stomatitis (RAS) treatment methods that could help patients in their daily lives.

Material and methods. A systematic literature review was performed of randomized control trials in English identified in MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane Library), Researchgate, published between 2018 and 2023. Studies had to be performed in vivo.

Results. 34 randomized clinical trials matched all criterias and were included in systematic literature review. A wide variety of topical and systemic agents are suggested for the treatment of RAS.

Conclusion. Topical medications can promote the healing time of ulcers and relieve the pain, but most of the time can not decrease the frequency of RAS relapse. However, for continuous RAS, treatment with systemic medication should be considered.

Key words: reccurent, aphthous, stomatitis, RAS, treatment, systematic review.

Received: 09 05 2022

Accepted for publishing: 24 03 2023

1UAB “SB dantu klinika”, LT49452 Kaunas, Lithuania

2Department of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspondence to Karolis Skučas, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Taikos pr. 65-23, 50436 Kaunas, Lithuania.

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