www.sbdmj.com - Stomatologija - Baltic Dental and Maxillofacial Journal

Stomatologija 2022; 24 (3): 80-4 156 KB

Photobiomodulation laser therapy in pemphigus vulgaris oral lesions: A randomized, double-blind, controlled study

Francesca Amadori^*, Elena Bardellini^*, Federica Veneri^*, Alessandra Majorana^*

Summary

Objective. Systemic corticosteroids are the mainstay treatment for PV oral lesions; the aim of this study is to evaluate the efficacy of PBMT with a 645 nm diode laser as a supportive topical therapy in patients with PV induced erosive-ulcerative oral lesions.

Materials and methods. This double-blind placebo-controlled study divided patients into two groups: A, patients receiving laser therapy (Raffaello 980 Bio, Dental Medical Technologies, Italy with the following parameters: 100 mW power, 645 nm wave length, irradiation area 1 cm², application time 30 sec/cm², energy density 3 J/cm², scanning modality) and B, receiving sham therapy (placebo). All patients were being treated also with a systemic corticosteroid therapy i.e. prednisone 0.5 mg/Kg per day. Size of lesions, VAS and satisfaction were evaluated before the treatment (T0), after 4 weeks (T1) and after 8 weeks as a follow-up (T2).

Results. A total of 50 lesions were evaluated. About lesions size, there was a statistical significative difference between the two groups just at T2 (p=0.0193), though VAS significantly decreased both at T1 (p=0.0198) and at T2 (p=0.0087). In general, all patients were satisfied of the treatment received.

Conclusion. PBMT can be considered a validate supportive therapeutic option, even if further RCTs studies with wide sample sizes and standardized management protocols are suggested.

Key words: oral ulcer, oral pemphigus, laser, pain.

Received: 27 02 2021

Accepted for publishing: 26 09 2022

^*Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, Brescia, Italy

Address correspondence to Francesca Amadori, Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P. le Spedali Civili 1 25123 Brescia, Italy.

E-mail address: francesca.amadori@unibs.it



	Baltic Dental and Maxillofacial Journal

2022, Vol. 24, No. 3 CONTENTS REVIEW Management of bisphosphonate-related osteonecrosis of the jaw using teriparatide treatment: A systematic review Abdulla Varoneckas, Rokas Gelažius, Vykintas Pliavga, Marijus Leketas, Ričardas Kubilius, Mariam Varoneckaitė 63-70 SCIENTIFIC ARTICLES Short-term postoperative changes in temporomandibular joints and masticatory muscles of Angle class II patients after mandibular advancement surgery: Clinical findings Heleia Nestal Zibo, Aleksei Baburin, Tiia Tamme, Ülle Voog-Oras 71-79 Photobiomodulation laser therapy in pemphigus vulgaris oral lesions: A randomized, double-blind, controlled study Francesca Amadori, Elena Bardellini, Federica Veneri, Alessandra Majorana 80-84 CASE REPORT Bardach’s triple-legged rotation flap as single-staged 3D helical upper-third reconstruction: A technical note Annette Wunsch, Andreas Neff, Jean-Paul Meningaud, Keskanya Subbalekha, Nattapong Sirintawat, Poramate Pitak-Arnnop 85-88 © 2023 Stomatologija		Stomatologija 2022; 24 (3): 80-4 156 KB Photobiomodulation laser therapy in pemphigus vulgaris oral lesions: A randomized, double-blind, controlled study Francesca Amadori^, Elena Bardellini^, Federica Veneri^, Alessandra Majorana^ Summary Objective. Systemic corticosteroids are the mainstay treatment for PV oral lesions; the aim of this study is to evaluate the efficacy of PBMT with a 645 nm diode laser as a supportive topical therapy in patients with PV induced erosive-ulcerative oral lesions. Materials and methods. This double-blind placebo-controlled study divided patients into two groups: A, patients receiving laser therapy (Raffaello 980 Bio, Dental Medical Technologies, Italy with the following parameters: 100 mW power, 645 nm wave length, irradiation area 1 cm², application time 30 sec/cm², energy density 3 J/cm², scanning modality) and B, receiving sham therapy (placebo). All patients were being treated also with a systemic corticosteroid therapy i.e. prednisone 0.5 mg/Kg per day. Size of lesions, VAS and satisfaction were evaluated before the treatment (T0), after 4 weeks (T1) and after 8 weeks as a follow-up (T2). Results. A total of 50 lesions were evaluated. About lesions size, there was a statistical significative difference between the two groups just at T2 (p=0.0193), though VAS significantly decreased both at T1 (p=0.0198) and at T2 (p=0.0087). In general, all patients were satisfied of the treatment received. Conclusion. PBMT can be considered a validate supportive therapeutic option, even if further RCTs studies with wide sample sizes and standardized management protocols are suggested. Key words: oral ulcer, oral pemphigus, laser, pain. Received: 27 02 2021 Accepted for publishing: 26 09 2022 ^*Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, Brescia, Italy Address correspondence to Francesca Amadori, Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, Dental School, University of Brescia, P. le Spedali Civili 1 25123 Brescia, Italy. E-mail address: francesca.amadori@unibs.it