|Baltic Dental and Maxillofacial Journal|
December, 2014, Vol. 16, No. 4
IRF6 AP-2a binding site promoter polymorphism is associated with oral clefts in Latvia
Mandibular morphology in monozygotic twins: a cephalometric study
© 2014 Stomatologija
Stomatologija 2014; 16 (4): 153-160 527 KB
Biologically active substances in bone morphogenesis. Literature review
Stasys Bojarskas, Regimantas Simuntis
Objectives. Understanding the mechanisms of bone morphogenesis is essential in solving problems related to reconstruction of bone defects. In a field of bone morphogenesis enormous array of biologically active substances have been proved as having more or less influence on bone growth, but no ideal guiding path for a new bone formation has been established yet. Therefore, bone tissue engineering, based on the laws of osteogenesis, becomes a significant niche for investigation. The aim of this article is to review recent scientific information concerning the role of bio substances in osteogenesis, their potentials in and future prospects.
Material and methods. Medline library database was searched, focusing on stem cells, osteoblast differentiation, bone growth factors and bone tissue engineering. Limits were review, research support. A quality assessment was carried out.
Results. A total of 63 articles matching our criteria were found: 20 reviews summarizing topics of growth factors, stem cells, tissue engineering and 43 articles representing studies of growth factors impact in osteoblast differentiation, bone regeneration and bone engineering.
Conclusions. The interactions among growth factors in osteoblast differentiation cascade are not fully understood. Moreover, methods of conversion of laboratory processes into clinically effective, reproducible, safe, economically viable and competitive products need to be improved.
Key words: bone morphogenesis, bone tissue engineering, growth factors, mesenchymal stem cells.
Received: 14 06 2014
Accepted for publishing: 20 12 2014
*Clinic of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
Stasys Bojarskas* – D.D.S., PhD, assoc. prof.
Regimantas Simuntis* – D.D.S.
Address correspondence to Dr. Stasys Bojarskas, Department of oral and maxillofacial surgery, Lithuanian University of Health Sciences, Kaunas Clinics, Eiveniu str. 2, LT-50009 Kaunas, Lithuania.
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