Baltic Dental and Maxillofacial Journal
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December, 2011, Vol. 13, No. 4



Dental management of patients before and after renal transplantation
Eleni A. Georgakopoulou, Marina D. Achtari, Niki Afentoulide

Factors influencing face aging. Literature review
Kestutis Sveikata, Irena Balciuniene, Janina Tutkuviene


Specific signaling molecule expression in periodontal ligaments in different age groups: Pilot study
Maris Grzibovskis, Ilga Urtane, Mara Pilmane

Upper airway sagittal dimensions in obstructive sleep apnea (OSA) patients and severity of the disease
Juris Svaza, Andrejs Skagers, Dace Cakarne, Iveta Jankovska


Endoscopically assisted enucleation of a large mandibular periapical cyst
Heleia Nestal Zibo, Ene Miller

Squamous cell carcinoma of the left temporal region
Albinas Gervickas, Raimundas Golubevas, Alvydas Gleiznys


© 2011 Stomatologija

Stomatologija 2011; 13 (4): 117-122 454 KB

Specific signaling molecule expression in periodontal ligaments in different age groups: pilot study

Maris Grzibovskis, Ilga Urtane, Mara Pilmane


Introduction. Orthodontic teeth movement is accompanied by remodeling of alveolar bone, including the interradicular septum and periodontal ligaments (PDL). Periodontal signaling molecules have important functions during tooth movement and they are active in the bone remodeling process. Patients involved in orthodontic treatment belong to different age groups: therefore age must be considered as a contributing factor compromising the remodeling potential of periodontal tissues. The aim of the current study was to investigate the specific expression of signaling molecules in the PDL of interradicular septum in patients from different groups of age.

Materials and methods. The study group included 25 patients to whom extractions of teeth was recommended as a part of further orthodontic treatment. 25 patients (10 males and 15 females) were divided into three groups as follows: 1) 12-14 years old; 2) 15-22 years old; and 3) 23 years old or older. The routine histological method was followed and samples were stained with hematoxyline-eosine. According to literature data in current immunohistochemical study were included and examined expression of NGFR (nerve growth factor receptor), TGF-β (transforming growth factor β), bFGF (basic fibroblast growth factor), FGFR1 (fibroblast growth factor receptor), IL-1 (interleukin 1), IL-6 (interleukin 6), IL-8 (interleukin 8), MMP-1 (matrix metalloproteinase 1), MMP-2 (matrix metalloproteinase 2), MMP-8 (matrix metalloproteinase 8), MMP-9 (matrix metalloproteinase 9), MMP-13 (matrix metalloproteinase 13) in PDL of interradicular septum. The distribution of these factors was evaluated semi quantitatively.

Results. Expression levels of FGFR1, bFGF, MMP 8 and 9, and IL-6 in PDL of interradicular septum structure were determined in all samples. Decreases in the mean values of signaling factors relevant to age were statistically significant in bFGF.

Conclusions. Analyzed data suggest that bFGF, FGFR, IL-6, MMP 8 and 9 were determined as signaling factors in PDL of interradicular septum. Mean expression level decrease with age of FGFR1, IL-6, MMP-8, MMP-9 was non- statistically significant. The mean expression level of bFGF decreased with age, and this decrease was statistically significant. In younger patients, signal molecule expression is higher because of increased PDL metabolic activity. Increased PDL metabolic activity is a reason for higher expression of signal molecule in younger patients. Activity of remodeling process of periodontal tissue decreases with the aging and expression of signaling molecule decreases in adults.

Key words: aging, bFGF, FGFR, MMP-8, MMP-9, IL-6.

Received: 04 07 2011

Accepted for publishing: 22 12 2011

1Department of Orthodontics, Institute of Stomatology, Riga Stradins University, Riga, Latvia

2Institute of Anatomy and Anthropology, Riga Stradins University, Riga, Latvia

Maris Grzibovskis1– D.D.S.

Ilga Urtane1 – D.D.S., PhD, prof.

Mara Pilmane2 – PhD, Dr. hab. med., prof.

Address correspondence to: to Maris Grzibovskis, Department of Orthodontics, Dzirciema str. 20, Riga, LV 1007, Latvia.

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