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Stomatologija 2010; 12 (1): 28-32 639 KB

Functional activity of rabbit salivary glands in reduced and restored regional arterial blood supply conditions

Kaspars Stamers, Andrejs Skagers, Kalvis Pastars, Nonna Tomisheva, Maija Ratniece

Summary

Background. Although the vascular pathology of carotid arteries is widespread, the function of salivary glands in reduced arterial flow conditions is not much investigated clinically and in experiments. At the same time blood supply is a keystone to normal functioning of every organ and especially of salivary secretion. The aim of this study was to estimate functional activity of salivary glands in reduced and restored blood supply conditions in experiment by sialoscintigraphy which is an approved method for functional assessment of salivary glands.

Methods. The ligature of a. carotis communis dextra was performed on 20 Californian rabbits. After 28 days sialoscintigraphy with Tc99 pertechnetate and revascularization through resection of the occluded part of a. carotis communis and reconstruction with venous autograft was performed. One month later sialoscintigraphy was done.

Results. The functional activity of rabbit salivary glands after the ligature of a. carotis communis is strongly depressed. The revascularized glands accumulated isotope slowly, but the level of accumulation was higher than on the control side.

Conclusion. The ligature and reconstruction of a common carotid artery on rabbits confirm the important role of the arterial blood supply in functional activity of salivary glands and may be an appropriate experimental model for investigation of ischemic disease of salivary glands.

Key words: sialoscintigraphy, carotid artery ligature.

Received: 13 10 2009

Accepted for publishing: 26 03 2010

¹Department of Oral and Maxillofacial Surgery, Riga Stradins University, Riga, Latvia

²Department of Reconstructive Microsurgery, University Hospital "Gailezers", Riga, Latvia

³Department of Radionuclide Diagnostics, Stradins University Hospital, Riga, Latvia

Kaspars Stamers¹ – MD, D.D.S.

Andrejs Skagers¹ – MD, Dr. hab. med, professor, Head of Department of Oral and Maxillofacial Surgery

Kalvis Pastars² – MD

Nonna Tomisheva² – MD

Maija Ratniece³ – MD

Address correspondence to Kaspars Stamers, Department of Oral and Maxillofacial Surgery, Dzirciema str. 20, Riga LV 1007, Latvia.

E-mail address: stamersons@inbox.lv



	Baltic Dental and Maxillofacial Journal

March, 2010, Vol. 12, No. 1 CONTENTS REVIEW Theory-based oral health education in adolescents Vilma Brukiene, Jolanta Aleksejuniene 3-9 SCIENTIFIC ARTICLES Oral health and quality of life in Norwegian and Russian school children: A pilot study Natalia Koposova, Eeva Widström, Martin Eisemann, Roman Koposov, Harald M. Eriksen 10-16 The effect of prednisolone on reduction of complaints after impacted third molar removal Janne Tiigimae-Saar, Edvitar Leibur, Tiia Tamme 17-22 Retrospective analysis of cellulitis of the floor of the mouth Linas Zaleckas, Ruta Rasteniene, Jurate Rimkuviene, Rimante Seselgyte 23-27 Functional activity of rabbit salivary glands in reduced and restored regional arterial blood supply conditions Kaspars Stamers, Andrejs Skagers, Kalvis Pastars, Nonna Tomisheva, Maija Ratniece 28-32 © 2010 Stomatologija		Stomatologija 2010; 12 (1): 28-32 639 KB Functional activity of rabbit salivary glands in reduced and restored regional arterial blood supply conditions Kaspars Stamers, Andrejs Skagers, Kalvis Pastars, Nonna Tomisheva, Maija Ratniece Summary Background. Although the vascular pathology of carotid arteries is widespread, the function of salivary glands in reduced arterial flow conditions is not much investigated clinically and in experiments. At the same time blood supply is a keystone to normal functioning of every organ and especially of salivary secretion. The aim of this study was to estimate functional activity of salivary glands in reduced and restored blood supply conditions in experiment by sialoscintigraphy which is an approved method for functional assessment of salivary glands. Methods. The ligature of a. carotis communis dextra was performed on 20 Californian rabbits. After 28 days sialoscintigraphy with Tc99 pertechnetate and revascularization through resection of the occluded part of a. carotis communis and reconstruction with venous autograft was performed. One month later sialoscintigraphy was done. Results. The functional activity of rabbit salivary glands after the ligature of a. carotis communis is strongly depressed. The revascularized glands accumulated isotope slowly, but the level of accumulation was higher than on the control side. Conclusion. The ligature and reconstruction of a common carotid artery on rabbits confirm the important role of the arterial blood supply in functional activity of salivary glands and may be an appropriate experimental model for investigation of ischemic disease of salivary glands. Key words: sialoscintigraphy, carotid artery ligature. Received: 13 10 2009 Accepted for publishing: 26 03 2010 ¹Department of Oral and Maxillofacial Surgery, Riga Stradins University, Riga, Latvia ²Department of Reconstructive Microsurgery, University Hospital "Gailezers", Riga, Latvia ³Department of Radionuclide Diagnostics, Stradins University Hospital, Riga, Latvia Kaspars Stamers¹ – MD, D.D.S. Andrejs Skagers¹ – MD, Dr. hab. med, professor, Head of Department of Oral and Maxillofacial Surgery Kalvis Pastars² – MD Nonna Tomisheva² – MD Maija Ratniece³ – MD Address correspondence to Kaspars Stamers, Department of Oral and Maxillofacial Surgery, Dzirciema str. 20, Riga LV 1007, Latvia. E-mail address: stamersons@inbox.lv